The influence of set-repetition configuration in eccentric exercise on muscle damage and repeated bout effect

It is well known that maximal eccentric exercise induces muscle damage, especially when it is performed for the first time. However, muscle damage is attenuated in subsequent bouts of the same or similar exercise, which is known as the repeated bout effect. One of the factors affecting the magnitude of muscle damage and the repeated bout effect is the number of eccentric contractions; however, it is unknown if different set-repetition configurations with the same number of eccentric contractions would result in different magnitudes of muscle damage and adaptation. This study investigated changes in muscle strength, range of motion (ROM), muscle cross sectional area (CSA), muscle soreness and plasma creatine kinase (CK) activity following an initial bout of maximal eccentric contractions with the same total number of contractions but different set-repetition configurations (e.g. 3 sets of 10 reps vs. 10 sets of 3 reps) and a second bout (20 sets of 3 repetitions) separated by four weeks. Since the present study was the first to use the ultrasound extended field of view (EFOV) technique to quantify bicep brachii CSA for an indication of muscle swelling, the reliability and validity of the technique were assessed in a separate study using 6 men (27.5 ± 1.9 y). In the main study, 10 non-resistance trained men (26.1 ± 4.1 y) performed two bouts of eccentric exercise of the elbow flexors for each arm (4 bouts in total). One arm performed 3 sets of 10 maximal eccentric contractions (3x10) followed 4 weeks later by 20 sets of 3 maximal eccentric contractions (20x3). The contralateral arm performed 10 sets of 3 maximal eccentric contractions (10x3) followed 4 weeks later by 20x3. The order of the exercise (3x10, 10x3) and the use of arm (dominant, non-dominant) were counterbalanced amongst subjects. Changes in the criterion measures over time and peak torque were compared among the initial bouts (3x10 vs. 10x3) and the repeated bouts (20x3 vs. 20x3) by a factorial repeatedmeasures analysis of variance (ANOVA) with two factors. Significance level was set at

Managing peer relationships online - Investigating the use of Facebook by juvenile delinquents and youths-at-risk

10.1016/j.chb.2012.04.025Computers in Human Behavior2918-15CHBE

Approximability of Connected Factors

Finding a d-regular spanning subgraph (or d-factor) of a graph is easy by Tutte's reduction to the matching problem. By the same reduction, it is easy to find a minimal or maximal d-factor of a graph. However, if we require that the d-factor is connected, these problems become NP-hard - finding a minimal connected 2-factor is just the traveling salesman problem (TSP). Given a complete graph with edge weights that satisfy the triangle inequality, we consider the problem of finding a minimal connected $d$-factor. We give a 3-approximation for all $d$ and improve this to an (r+1)-approximation for even d, where r is the approximation ratio of the TSP. This yields a 2.5-approximation for even d. The same algorithm yields an (r+1)-approximation for the directed version of the problem, where r is the approximation ratio of the asymmetric TSP. We also show that none of these minimization problems can be approximated better than the corresponding TSP. Finally, for the decision problem of deciding whether a given graph contains a connected d-factor, we extend known hardness results.Comment: To appear in the proceedings of WAOA 201

Oxidative stress in fetal programming of cardiometabolic syndrome

Cardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments; a phenomenon known as fetal programming of adult disease. This mini-review discusses [1]how exposures to various insults from the mother during gestation and/or lactation programs the fetus that prompts the development of CMS during adulthood; [2] what are the currently known underlying mechanisms, with emphasis on the role of tissue oxidative stress; and [3] whether CMS in the offspring can be reprogrammed via targeting maternal tissue oxidative stress. Translational perspective of the research field is also discussed.Sociedad Argentina de Fisiologí

The Role of Translation Initiation Regulation in Haematopoiesis

Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors. Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression. This paper outlines how these posttranscriptional control mechanisms, including control at the level of translation initiation factors and the role of RNA binding proteins, affect hematopoiesis. The clinical relevance of these mechanisms in haematological disorders indicates clearly the potential therapeutic implications and the need of molecular tools that allow measurement at the level of translational control. Although the importance of miRNAs in translation control is well recognised and studied extensively, this paper will exclude detailed account of this level of control

What is the most effective method of pain reduction during intravenous cannulation in children? A systematic review and meta-analysis study

Introduction: Pain is one of the various outcomes of intravenous cannulation. There are various methods of pain reduction during intravenous cannulation. Still there is not any agreement about the most effective analgesic method. For this reason, the aim of this study was to determine the most effective method of pain reduction during intravenous cannulation in childrenn. Materials and methods: All previous relevant studies in the databases were reviewed using Cochrane protocol and sensitive and standard keywords such as pain, children and intravenous cannulation, from 1995 to 2013. The extraction and evaluation of studies were performed by two individuals. CONSORT checklist was used to evaluate the quality of the studies. Samples homogeneity was assessed using the tau-square estimates. The random effects model was used to report the pooled average estimates for the most effective method on pain reduction during intravenous cannulation. Results: systematic review of 14409 studies determined that only 30 studies had the inclusion criteria. Nineteen studies were entered the meta-analysis. Meta-analysis study showed that EMLA was the most effective method in comparing control/ placebo among the other various ones. Among the treatments comparison, IontophoresisLidocaine was the most effective in compare with EMLA. Conclusion: EMLA cream was the most effective treatment in reducing the pain of intravenous cannulation. Although lidocaine injection methods such as Iontophoresis, as a new method, can produce more rapid, effective and satisfying pain reduction than other alternatives. © 2016, Semnan University of Medical Sciences. All rights reserved

Reliability and validity of the persian version of templer death anxiety scale-extended in veterans of Iran-Iraq warfare

Objective: The purpose of this study was to determine the validity and reliability of the Persian version of Templer Death Anxiety Scale-Extended (DAS-E) in veterans of Iran-Iraq Warfare. Methods: In this cross-sectional study, 211 male veterans of Iran-Iraq Warfare completed the 51 item DAS-E. Principal components analysis with varimax rotation was used to assess domain structure of the DAS-E. Internal consistency reliability was assessed with Cronbach's alpha. Test-retest reliability was assessed with intra-class correlation coefficients for absolute agreement for the individual items and domains. Results: The construct validity of the scale was obtained using exploratory factor analysis that showed four factors with Eigen values of greater than 1 (1, 11 items, α = 0.83; 2, 7 items; α = 0.87; 3, 5 items, α = 0.73; and 4, 4 items, α = 0.75). Test-retest and internal consistency (total alpha) was 0.91 and 0.89, respectively. Conclusion: The DAS-E demonstrated suitable validity and reliability among the veterans under study. The factor analysis demonstrated that the DAS-E has a multi-dimensional structure. With consideration of the proper psychometric characteristics, this scale can be used to further research about death anxiety in this population